Director, Toxicology Job at Ventyx Biosciences, San Diego, CA

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  • Ventyx Biosciences
  • San Diego, CA

Job Description

Ventyx Biosciences, Inc. is a clinical-stage, public biopharmaceutical company focused on advancing new therapies for millions of people living with inflammatory diseases and autoimmune disorders. We are developing novel and differentiated therapeutics that target both the innate and adaptive immune system. Our clinical-stage programs include an allosteric TYK2 inhibitor for the treatment of a broad range of autoimmune diseases, an S1P1 receptor modulator for the treatment of ulcerative colitis, and both peripheral and CNS inhibitors of the NLRP3 inflammasome, which is a mediator of multiple inflammatory conditions. Join this team of life science professionals to bring this portfolio of programs to fruition.

The Opportunity: Director, Toxicology:

The Director, Toxicology will be responsible for toxicology strategy, study design and management to support successful regulatory submissions from IND to NDA. The successful candidate will oversee and coordinate all toxicology assays designed to determine toxicities of small molecules intended for human therapeutic use. All experimental work will be conducted at contract research organizations (CROs).

What You Will Contribute:

  • Serves as the internal toxicology expert with ability to generate and execute on toxicology strategy from discovery stage to regulatory approval.
  • Generates a toxicology strategy for each asset/program.
  • Designs, oversees and manages the conduct of toxicology work on the company’s timeline.
  • Designs, as needed, experiments to define any identified toxicities.
  • Provides interpretation of the data including graphical representation and context within the drug discovery and development effort.
  • Reviews and finalizes toxicology reports in a timely manner.
  • Collaborates and contributes to multidisciplinary teams in the progression of discovery candidates to clinical candidacy to regulatory approval.
  • Confers with outside experts, including toxicologists, regulatory strategists and ADME specialists.
  • Represents the Company/program teams at scientific conferences.
  • Contributes to regulatory documents, including authoring IND sections.
  • As part of the Company’s regulatory strategy, interacts directly with regulators as requested.

What We Seek:

  • Ph.D with 10 years of experience in toxicology in a drug discovery and development environment.
  • Diplomate of the American Board of Toxicology preferred.
  • Prior experience writing regulatory section for an IND and NDA submission, and deep knowledge of FDA and ICH guidance pertaining to toxicology.
  • Can effectively communicate with internal and external scientific teams, and all levels of management.
  • Ability to share expert knowledge in a diversely trained team environment.
  • Possesses the ability to write clear and concise technical reports, presentations, and business correspondence.
  • Ability to plan experiments, organize self and others, and oversee multiple efforts remotely.
  • Demonstrated agility to learn, and prioritize multiple responsibilities independently, remove barriers and drive projects to completion.
  • Strong oral & written scientific communications skills.
  • Good presentation skills for diverse audiences (investigator meetings, site personnel, KOL interactions and internal project teams).
  • Ability to strike a balance between independent work and team interaction, be a team player in a cross-functional team.
  • Well-developed interpersonal skills, with experience in interacting with and influencing people, building strong positive relationships.
  • Proficiency in Microsoft Office and other productivity tools with an aptitude to learn new software and systems; ability to work with large databases.

What We Provide to You:

  • The opportunity to make a difference in people’s lives impacted by autoimmune and inflammatory diseases.
  • Participate in a team of life science professionals who value science, data, high work ethic and a meritocracy; access to all levels of the organization to get work done with a sense of urgency.
  • Competitive compensation and a comprehensive benefit package, including stock options.

Ventyx is an equal opportunity employer and encourages potential or current employees to request a reasonable accommodation under federal, state and local regulations, should one be needed. The anticipated annual base salary range for this role is $200,000 to $230,000. Final compensation depends on multiple factors including but not limited to, relevant experience, skillset, depth and breadth of knowledge, internal equity, company needs, and market factors. Ventyx is a rapidly growing biotech company that offers competitive wages and benefits package including medical, dental, vision, LTD, time off, a retirement plan, and other voluntary benefits for employees.

Notice to Recruiters and Agencies:

The Human Resources team manages the recruitment and employment process for Ventyx Biosciences. To protect the interest of all parties involved, Ventyx Biosciences does not accept unsolicited referrals or resumes from any source other than directly from candidates. We will not consider unsolicited referrals and/or resumes from vendors including and without limitation, search firms, staffing or recruiting agencies or fee-based referral services. The submission of referrals or resumes by anyone other than a candidate directly to Ventyx Biosciences’ employees is strictly prohibited. Unsolicited referrals and resumes sent to Ventyx are deemed gratuitous, and do not obligate Ventyx to pay fees should we hire from those resumes. Recruiters are requested NOT to contact or present candidates directly to our hiring managers or employees. Please direct all inquiries to careers@ventyxbio.com.

Job Tags

Full time, Contract work, Local area, Remote job,

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