Job Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at  . Follow @abbvie on  Twitter ,  Facebook ,  Instagram ,  YouTube and  LinkedIn . 

Job Description

Investigative Toxicology and Pathology group within Preclinical safety department is seeking a highly motivated and skilled Scientist to join our team to perform lab based molecular toxicology work. This position in Molecular toxicology subgroup entails conducting fit for purpose toxicological evaluations of drug candidates, examining tissue/system responses to compound exposure, and elucidating of mechanisms of toxicity utilizing the novel in vitro (focusing on immune competent MPS/complex in vitro models) and ex vivo systems incorporating genomic and imaging technologies. Candidates would be expected to build, characterize, evaluate, and implement new in vivo relevant human and preclinical species complex in vitro/MPS models for drug development applications. Also, would be responsible to support routine investigative toxicology assays/screening for drug discovery and development programs. Opportunity to interact and work closely with project toxicologists and other colleagues in the group including molecular biologists, computational toxicologists, and veterinary pathologists. Candidates will have support to be involved in external consortium activities with an opportunity to share investigative toxicology results in key external scientific meetings.

Responsibilities:

• Independently generate plan for hypothesis driven research to predict and/or to understand potential mechanisms of toxicities supporting preclinical and clinical stages of drug development.
• Build and characterize novel in vivo relevant human in vitro (e.g., 3D spheroids and MPS) and ex vivo platforms. In addition to human models, contribute to building and optimizing preclinical species in vitro models as relevant to understand cross species translatability and mechanistic understanding of species-specific toxicities.
• Implementing high content imaging and genomic (bulk sequencing and single cell sequencing) endpoints in in vitro assays
• Implement learnings from in vitro and ex vivo studies to identify appropriate biomarker for exploratory in vivo studies
• Oversee complex in vitro model related activities within preclinical safety and train junior technical staff
• Interpret data, summarize and communicate with project team and other key stakeholders
• Identify opportunities to present the data at external meetings and publish key results, and assist/design in vivo investigative toxicology studies to understand mechanisms of toxicity and/or to identify new potential safety biomarkers. 
• Responsible for maintaining lab equipment’s and resources related to in complex in vitro models
• Generate reliable and consistent results to further project goals in a timely manner.
• Analyze and interpret results and formulate conclusions from multidisciplinary experiments, design and pursue relevant follow-on experiments.

Qualifications

Qualifications

Abbvie is looking for individuals that possess a positive can-do attitude, are motivated by doing a job well, are adaptable and flexible, have a continuous improvement mindset, and will thrive in a fast-paced collaborative and diverse environment. In addition, successful candidates will have the following:

• PhD in Molecular toxicology, Immunology, Pharmacology, Cell/Molecular Biology or related field with typically 0 to 5 years of academic or industry experience in building and characterization of complex in vitro models to support efficacy and or safety evaluation.
• Strong knowledge of complex in vitro models/MPS with technical proficiency in standard cellular and molecular biology techniques
• Previous experience in toxicology, drug discovery and/or translational research is preferred.
• Experience in incorporating immune cells in in vitro models and using these models to detect immune mediated toxicity is a plus
• Strong verbal and written communication, organizational, critical thinking / problem-solving, analytical, and interpersonal/team skills.
• Knowledge of small molecules and large molecules drug development and key safety challenges.
• Knowledge of high content imaging

Position will be filled at level commensurate with extent of education, experience, and accomplishment.
Sr Scientist I or Sr Scientist II

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

·The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

·We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

·This job is eligible to participate in our short-term incentive programs. 

·This job may be eligible to participate in our long-term incentive programs

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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